This paper presents a complete analysis of the mathematical model of the gene regulation process. The model describes the induced gene expression under the effect of activators. The model differential equations are solved analytically, and the exact solution of the gene model is introduced. Moreover, a study of the model dynamics, including the fixed points and stability conditions are presented. The parameters effects on the phase plane portraits and the transient responses of the mRNA as well as the protein concentrations are intensively detailed. This work serves as a brick stone towards a complete model for a complete gene regulation biological process for future prediction and control of diseases at the genetic level. © 2018 IEEE.
Ismail S.M., Said L.A., Radwan A.G., Madian A.H., Abu-Elyazeed M.F.
activator; Gene regulation; modeling; stability; transcription; translation
2018 7th International Conference on Modern Circuits and Systems Technologies, MOCAST 2018, PP. 1 to 4, Doi: 10.1109/MOCAST.2018.8376618